Effect of acetaminophen prophylaxis on ductus arteriosus closure in premature infants
Phase 3
Recruiting
- Conditions
- Delayed closure of ductus arteriosus.Persistent fetal circulation
- Registration Number
- IRCT20190305042935N1
- Lead Sponsor
- Shahre-kord University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Premature infants admitted to the neonatal intensive care unit
Weight under 1500 grams
Age under 31 weeks
Exclusion Criteria
Infants with congenital heart defects, congenital major abnormalities or chromosomal abnormalities
Infants whose mothers have a history of using nonsteroidal anti-inflammatory drugs during pregnancy
Infants with hydrops fetalis
Infants with Apgar scores greater than 5 at five minutes after birth
Infants with symptomatic PDA require treatment with ibuprofen
Infants have vomiting or hematems in the first three days of birth
Infants with high levels of liver enzymes
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ductus arteriosus status. Timepoint: Ten and thirty days after intervention. Method of measurement: Echocardiography.
- Secondary Outcome Measures
Name Time Method