Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
- Conditions
- Gastroesophageal Reflux
- Registration Number
- NCT00231881
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
- Detailed Description
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Main inclusion criteria :
- Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- Need of upper GI endoscopy and pH monitoring.
- Normal propagation of oesophageal persitaltic waves (manometry < 6 months).
- Age 18 -70 yrs
- Signed informed consent
- Normal coagulation
- Barrett's oesophagus
- Previous oesophageal bleeding
- Need of NSAID treatment.
- Previous sus mesocolic surgery
- Alcool consumption > 40g/d, smoking > 10 cig/j
- Pregnancy or lack of contraceptive disposal, breast feeding.
- Allergy to Xylocaïne
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Nantes University Hospital
🇫🇷Nantes, France