Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
详细描述
This study aims to characterize the permeability as well as some protein involved in the cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition these patients will be characterized for their reflux especially by pH-impedancemetry, Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of the reflux and the biological results will be calculated.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Main inclusion criteria :
- •Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- •Need of upper GI endoscopy and pH monitoring.
- •Normal propagation of oesophageal persitaltic waves (manometry < 6 months).
- •Age 18 -70 yrs
- •Signed informed consent
- •Normal coagulation
排除标准
- •Barrett's oesophagus
- •Previous oesophageal bleeding
- •Need of NSAID treatment.
- •Previous sus mesocolic surgery
- •Alcool consumption > 40g/d, smoking > 10 cig/j
- •Pregnancy or lack of contraceptive disposal, breast feeding.
- •Allergy to Xylocaïne