Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction

Not Applicable

Completed

• Conditions: Isolated Anterior Cruciate Ligament Rupture
• Interventions: Other: Autograft harvest contralateral to ACL-deficient leg; Other: Autograft STG harvest from ACL-deficient leg

• Registration Number: NCT01537588
• Lead Sponsor: Panam Clinic

Brief Summary

The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction. There are three main components of this study:

1. How do muscle shape, size, strength, and ability to function change following hamstring grafting for ACL reconstruction;

2. How does physical activity change following ACL reconstruction;

3. Is there a difference in outcome if graft harvest is done from the injured versus uninjured limbs

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07
• Study First Submitted: 2012-02-14
• Study First Submitted QC: 2012-02-17
• Study First Posted: 2012-02-23
• Primary Completion: 2012-07
• Study Completion: 2012-07
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-09
• Last Update Posted: 2015-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• between 18 and 50 years old; isolated ACL rupture confirmed on MRI

Exclusion Criteria

• other physical or mental health issues that affect ability to complete rehabilitation and/or study follow-ups

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Autograft harvest of STG from ACL-deficient leg	Autograft harvest contralateral to ACL-deficient leg	Autograft harvest of STG from leg contralateral to ACL-deficient leg
Standard	Autograft STG harvest from ACL-deficient leg	ACL reconstruction with autograft harvest of STG from ACL-deficient leg

Primary Outcome Measures

Name	Time	Method
Muscle cross sectional area	12 months post-surgery	Measured on bilateral MRI taken from ischial tuberosity to 10 cm below knee joint line

Secondary Outcome Measures

Name	Time	Method
Physical activity	12 months post-surgery	7-day record of activity using accelerometer.
Knee flexion and extension isokinetic strength	12-months post-surgery	Eccentric anc concentric strength measured at 60, 150, and 270 degrees/second on dynamometer in sitting and in 5 degrees hip flexion

Trial Locations

Locations (1)

Pan Am Clinic; 🇨🇦 Winnipeg, Manitoba, Canada