Physical Exercise and Nutrition Supplement on Improving Frailty, Depressive Symptoms, and Quality of Life in Community-dwelling Older Population
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Taipei Medical University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- frailty score
Study Overview
Brief Summary
This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.
Detailed Description
Objective
This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.
Methods: We conduct a quasi-experimental study to measure frailty, depressive symptoms, and quality of life before and after intervention. A total of 120 community-living older adults with frailty identified by Fried's phenotype method are assigned to four groups: physical exercise group, nutrition supplements group, physical exercise and nutrition supplements group, and control group. Each participants in the assigned group will receive 12 weeks intervention. Measurements include frailty (Fried's phenotype method), depressive symptoms (Geriatric Depression Scale-15, GDS-15), and quality of life (WHOQOL-BREF). Data analyses include describe statistics, Chi-square test, and Analysis of Variance. A Generalized estimating equations (GEE) will be used to examine the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 60 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •older adults aged more than 60 years;
- •pre-frail stage: must have one item as frailty identified using the Fried's phenotype method;
- •normal cognition: AD8 score less than 2 points;
- •can communicate with Mandarin or Taiwanese.
Exclusion Criteria
- •incapable of walk independent or using assistive devices (e.g., crutches);
- •a condition of having an acute disease, hemodialysis, or unable to engage in physical activity;
- •have history of unstable heart disease such as coronary heart disease, heart failure and hypertension without regular medication;
- •have regular physical activity (≥150 minutes weekly) such as aerobic dance, swimming, Tai Chi.
Arms & Interventions
Individual physical exercise group
a 12-weeks physical exercise program (60 minutes/ three times weekly)
Intervention: individual physical exercise group (Behavioral)
Individual Branched-Chain Amino Acids supplements group
a 12-weeks Branched-Chain Amino Acids supplements (5 g Branched-Chain Amino Acids every day)
Intervention: individual Branched-Chain Amino Acids supplements group (Dietary Supplement)
Combination of physical exercise and Branched-Chain Amino Acids supplements group
a 12-weeks physical exercise program (60 minutes/ three times weekly) and a 12-weeks Branched-Chain Amino Acids supplements (5 g Branched-Chain Amino Acids every day)
Intervention: combination of physical exercise and nutrition supplements group (Other)
Control group
no intervention
Outcomes
Primary Outcomes
frailty score
Time Frame: through study completion, an average of 12 weeks
Frailty will examined using Fried's phenotype method and higher score indicates more frailty
frailty score
Time Frame: frailty score at baseline
Frailty will examined using Fried's phenotype method and higher score indicates more frailty
Secondary Outcomes
- Quality of Life score(through study completion, an average of 12 weeks)
- Depressive symptoms score(through study completion, an average of 12 weeks)
- Depressive symptoms score(Depressive symptoms at baseline)
- Quality of Life score(Quality of Life at baseline)
Investigators
Huang, Hui-Chuan
associate professor
Taipei Medical University