Herpes Zoster: Risk Factors, Complications and Special Situations

Completed

• Conditions: Herpes Zoster

• Registration Number: NCT03903237
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This retrospective analysis is to investigate patients' history and clinical presentation in Herpes Zoster (HZ), Zoster-related complications, post-Zoster neuralgia and Herpes Zoster management in order to improve the management of HZ patients, to refine HZ-vaccination strategies and elucidate cost factors of HZ in in the setting of a university hospital in Switzerland generally and in a dermatology department specifically.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-20
• Primary Completion: 2019-02-28
• Study Completion: 2019-02-28
• Status Verified: 2019-04
• Study First Submitted: 2019-04-02
• Study First Submitted QC: 2019-04-03
• Last Update Submitted: 2019-04-03
• Study First Posted: 2019-04-04
• Last Update Posted: 2019-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 355

Inclusion Criteria

• Reports of patients with HZ at University Hospital Basel between 2004-2018

Exclusion Criteria

• rejection to use patient data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of patients' history	single time point assessment at baseline	Free text evaluation of patients' history (age, sex, comorbidities, immunosuppression, obesity, human immune deficiency Virus (HIV), profession, current medication, vaccinations, seasonal occurence of HZ, history of Varicella Zoster virus (VZV) infection
Description of the clinical presentation of HZ	single time point assessment at baseline	Free text description of the clinical presentation of HZ (localisation, dermatomes affected), Zoster-related acute pain
Evaluation of the herpes zoster management	single time point assessment at baseline	Free text evaluation of the herpes zoster management (local (antiviral) treatment, systemic antiviral and other treatments, number of revisits, average treatment-related costs, hospitalisations (rate, duration)
Assessment of post-zoster neuralgia	single time point assessment at baseline	Free text assessment of post-zoster neuralgia (annual incidence, treatment options used)
Evaluation of zoster and pregnancy	single time point assessment at baseline	Free text evaluation of zoster and pregnancy (incidence, time of pregnancy, pregnancy outcomes and complications)
Evaluation of zoster-related complications	single time point assessment at baseline	Free text evaluation of zoster-related complications (ophthalmic zoster, generalised HZ, Ramsay-Hunt syndrome, zoster meningoencephalitis)

Trial Locations

Locations (1)

Department of Dermatology, University Hospital Basel; 🇨🇭 Basel, Switzerland