A comparative study on the block characteristics in spinal anaesthesia with premixed or succedent administration of hyperbaric bupivacaine and fentanyl in lower segment caesarean section

The study will be a prospective randomized double blinded study to assess and compare the effects of premixed or succedent intrathecal administration of 25 mcg fentanyl citrate with 0.5% bupivacaine (2ml , heavy) in parturient undergoing LSCS procedures under subarachnoid block.

A total of 60 parturient will be selected for the study and divided into 2 groups of 30 patients each viz. group A (n-30) and group B (n-30). According to block randomization, patients in group A will be administered premixed 2ml of 0.5% bupivacaine heavy plus 0.5 ml  (25mcg) fentanyl citrate with a 5 ml syringe and group B will be administered 2ml of 0.5% bupivacaine heavy in a 5ml syringe followed by 0.5 ml (25mcg) fentanyl citrate with a 2ml syringe in the subarachnoid space L3-L4. in both the groups, the study drugs will be administered  at a rate of 0.2ml/min. The block characteristics along with regression of the blockade, side effects (if any) and the hemodynamic changes will be observed, assessed and recorded by blinded investigator using the modified bromage scale, VAS, sedation scale.

The data collected will be collected and analyzed using student t test for continuous data and chi square test for categorical data as and where appropriate.