Correlation Between Vitamin D and B Regulatory Cell in Pregnancy

• Conditions: Labor, Premature

• Registration Number: NCT04105881
• Lead Sponsor: Assiut University

Brief Summary

During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.

Detailed Description

During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.the fetus is normally accepted by the maternal immune system despite despite the expression of paternal alloantigens. Normally, the fetus grows and develops very well with ongoing pregnancy.

B regulatory cells are increased in pregnant women compared to non-pregnant women.

Study Timeline

• Status Verified: 2019-09
• Study First Submitted: 2019-09-25
• Study First Submitted QC: 2019-09-25
• Last Update Submitted: 2019-09-25
• Study First Posted: 2019-09-26
• Last Update Posted: 2019-09-26
• Study Start: 2020-02-10
• Primary Completion: 2020-03-10
• Study Completion: 2020-03-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• healthy female according to the required groups

Exclusion Criteria

• patient with infectious disease , tuberculosis ,tumor ,hematologic disease,metabolic bone disease or any other connective tissue diseases were excluded.
• Patient with viral hepatitis.
• serological evidence of HIV infection.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in number of B regulatory cell in pregnant woman	9 months	Immune system immunosuppressed to maintain fetus

Trial Locations

Locations (1)

Assiut university; 🇪🇬 Assiut, Egypt