Correlation Between Vitamin D and B Regulatory Cell in Pregnancy
- Conditions
- Labor, Premature
- Interventions
- Dietary Supplement: Investigation
- Registration Number
- NCT04105881
- Lead Sponsor
- Assiut University
- Brief Summary
During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.
- Detailed Description
During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.the fetus is normally accepted by the maternal immune system despite despite the expression of paternal alloantigens. Normally, the fetus grows and develops very well with ongoing pregnancy.
B regulatory cells are increased in pregnant women compared to non-pregnant women.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
- healthy female according to the required groups
Exclusion Criteria
- patient with infectious disease , tuberculosis ,tumor ,hematologic disease,metabolic bone disease or any other connective tissue diseases were excluded.
- Patient with viral hepatitis.
- serological evidence of HIV infection.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Full term labor Investigation Measured by flow cytometry and ELUSA Preterm labor Investigation Measured by flow cytometry and ELISA Control Investigation For comparison
- Primary Outcome Measures
Name Time Method Changes in number of B regulatory cell in pregnant woman 9 months Immune system immunosuppressed to maintain fetus
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assiut university
🇪🇬Assiut, Egypt