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Clinical Trials/NCT02691364
NCT02691364UnknownNot Applicable

Different Regulation of Immune Cells in Patients With Preeclampsia

University Medical Center Groningen0 sites30 target enrollmentStarted: April 2016Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Enrollment
30
Primary Endpoint
Cell levels
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 40 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •written informed consent
  • •18-40 years

Exclusion Criteria

  • •immune related disorders (other than preeclampsia)
  • •fever / illness within the last month
  • •infertility
  • •body mass index <18 or >30

Outcomes

Primary Outcomes

Cell levels

Time Frame: 1 year

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Jelmer Prins

MD PhD

University Medical Center Groningen

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Different Regulation of Immune Cells in... | Clinical Trial