Effects of Negative Pressure Ventilation Onto Hemodynamics and Right Ventricular Funktion in Patients After Implantation of a Left Ventricular Assist Device.
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Karlsburg Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- RVSWI
Overview
Brief Summary
All patients undergoing an implantation of a durable left ventricular assist device and monitored by pulmonary artery catheter showing no adverse events after surgery are included in the study and ventilated for 15 minutes using extra thoracic negative pressure ventilation and usual intrathoracic positive pressure ventilation. Hemodynamics changes between both ventilation modes, especially focussing on right ventricular function and measured by a pulmonary artery catheter, are compared.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All patients after implantation of a durable left ventricular assist device
Exclusion Criteria
- •Complication during surgery like bleeding, emergency, inability to fit the cuirass, unavailability of an investigator, unstable condition regarding circulation or ventilation
Arms & Interventions
All participants negative pressure ventilation and positive pressure ventilation
Intervention: Negative pressure ventilation (Device)
All participants negative pressure ventilation and positive pressure ventilation
Intervention: positive pressure ventilation (Device)
Outcomes
Primary Outcomes
RVSWI
Time Frame: one minute
right ventricular stroke work index
Secondary Outcomes
No secondary outcomes reported
Investigators
Prof. Dr. Matthias Heringlake
Head of department for anesthesiology and critical care
Karlsburg Hospital