Effects of Thai Dance With Twenty-five Squares on Cerebrovascular and Cognitive Function in Elderly With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- The Trail Making Test B Thai modified (TMT-B)
研究概览
简要总结
The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment
详细描述
Twenty elderly with mild cognitive impairment aged 60 years and over were randomized into 2 groups: control group (CON; n=20) and Thai dance with twenty-five squares training group (TDT; n=20). Participants in CON group do their daily routine without receiving any training program, while those in TDT group completed receiving Thai dance with twenty-five squares training program three time a week for twelve week-long (60 minutes/time). The physiological data, cerebrovascular function, cognitive, respiratory function, health-related physical fitness, and Blood biochemistry variables were analyzed during the pre-test and post-tests. The dependent variables between pre-test and post-tests were analyzed by paired t-test. The variables between pre-test and post-test were analyzed by paired t-test. In addition, an independent t-test was used to compare the variables between groups. Statistical significance was defined as p < .05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elderly males and females aged 60-79 years who can lead normal daily lives. Individuals with mild cognitive impairment identified through the Montreal Cognitive Assessment (MoCA) with a score in the range of 17 -
- •Must be able to listen, speak, read, write, and understand the Thai language.
- •Should not have diseases or abnormalities such as heart disease, eye complications caused by diabetes, uncontrolled high blood pressure, kidney complications caused by diabetes, and stroke.
- •Must not have other respiratory diseases such as tuberculosis (Tuberculosis), asthma (Asthma), lung cancer (Lung cancer), emphysema (Emphysema), chronic obstructive pulmonary disease (COPD), etc.
- •Must be a person not at risk of falling, determined through a test of the ability to walk and turn 3 meters within a time period of 7 - 15 seconds.
- •Must not have received medication to treat dementia.
- •Should not have received exercise training for more than 20 minutes at a time, 3 days/week, or more in the past 6 months before participating in the research.
- •Should not have symptoms of mental disorders such as schizophrenia, bipolar disorder, or depression.
- •Should have passed the pre-exercise readiness assessment (PAR-Q).
- •Must be willing to participate in the research and sign the consent form to take part in the study.
排除标准
- •A force majeure event, such as illness, that prevents participation in the research.
- •Participation in less than 80% of the research sessions (must participate 29 times out of 36 times).
- •Unwillingness to continue participating in the research.
结局指标
主要结局
The Trail Making Test B Thai modified (TMT-B)
时间窗: Change from baseline TMT-B testing time at 12 weeks.
The Trail Making Test B Thai modified (TMT-B) is a subtest in the Halstead-Reitan Neuropsychological test, adapted into Thai. The criteria for normalcy is set at no more than 89 seconds for individuals aged 60 years and over. The test includes numbers 1-13 and month abbreviations in Thai (Jan. - Dec.), totaling 25 characters, which consist of numbers and/or letters. They are arranged in a distributed manner, and when connecting lines are drawn, they will not intersect. The TMT-B serves as an assessment of cognitive ability, focusing on concentration and management.
The Mini-Mental State Examination Thai (MMSE-T)
时间窗: Change from baseline MMSE-T scores at 12 weeks.
The Mini-Mental State Examination Thai (MMSE-T) is a preliminary brain condition test that comprises 11 topics with a maximum score of 30 points. This basic brain state test is utilized to assess various aspects of cognition, including awareness of surrounding conditions, perception of time, spatial orientation, concentration and calculation, language use, and repetition.
Intima-Media Thickness (IMT) test
时间窗: Change from baseline Intima-Media Thickness (IMT) at 12 weeks.
Intima-Media Thickness (IMT) is a test conducted on the carotid artery on the side of the neck. Using an ultrasound machine (Philips, EPIQ 5G, USA), the thickness of the carotid artery walls was measured 1-2 cm away from the carotid bulb. Participants had their necks tilted 45 degrees. The artery walls were measured and then analyzed for thickness using the QLAB program.
The Monreal Cognitive Assessment (MoCA-T)
时间窗: Change from baseline MoCA-T scores at 12 weeks.
The Monreal Cognitive Assessment, known as MoCA-T, is a questionnaire comprising 11 topics with a maximum score of 30 points. It serves as a comprehensive tool for assessing various aspects of cognitive intelligence in various areas, including management, naming, concentration, language use, and abstract thinking.
Brain oxygen saturation levels
时间窗: Change from baseline Brain oxygen saturation levels at 12 weeks.
Brain oxygen saturation levels are assessed in the frontal lobe area using an oxygen saturation level meter (Universal Oximetry System), measured in percentage units. The evaluation is performed with a brain oxygen saturation level assessment device, specifically the SenSmart® Model X-100 (SenSmart® Model X-100, USA).
Cerebrovascular reactivity
时间窗: Change from baseline Cerebrovascular reactivity at 12 weeks.
Cerebrovascular reactivity is a test that assesses the response of cerebral blood vessels to carbon dioxide. This test analyzes the ability of cerebral blood vessels to contract and expand. Using an ultrasound machine and a probe with a frequency of 5 to 1 MHz, the partial pressure of CO2 is altered, and Cerebral Blood Flow Velocity (CBFV) is measured in the left middle cerebral artery at an examination depth of 30-65 mm. The variables used for analysis include Time-Averaged Peak Velocity (TAPV), Peak Systolic Velocity; PSV, End Diastolic Velocity; EDV, and Cerebral Blood Vessel Resistance (Pulsatility Index; PI).
Brachial-ankle pulse wave velocity (baPWV)
时间窗: Change from baseline Brachial-ankle pulse wave velocity (baPWV) at 12 weeks.
Brachial-ankle pulse wave velocity (baPWV) is utilized to indicate the arterial stiffness. This noninvasive test measure the time difference in blood pumping (brachial-ankle time delay) between the brachial artery and the posterior tibial artery. The length between both measurement points is then measured, and the pulse pressure wave between the upper arm and ankle is calculated (Brachial-ankle pulse wave velocity: baPWV), with the participant lying on their back on a bed. Next, both wrists and the left upper chest are cleaned with alcohol. The researcher then attaches cuffs to both the participants' arms and ankles, and electrodes of the device for measuring electrocardiograms are attached to the wrists. Additionally, cardiac sound waves (PCG) are placed on the left side near the sternum (Sternal notch).
次要结局
- Pulmonary function (Forced vital capacity; FVC)(Change from baseline FVC at 12 weeks.)
- The Back Scratch test(Change from baseline The Back Scratch test scores at 12 weeks.)
- The Chair Stand test(Change from baseline The Chair Stand test scores at 12 weeks.)
- Pulmonary function (The ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lungs; FEV1/FVC)(Change from baseline FEV1/FVC at 12 weeks.)
- Blood chemical data test(Change from baseline blood chemical data at 12 weeks.)
- Pulmonary function (Maximal voluntary ventilation; MVV)(Change from baseline MVV at 12 weeks.)
- The Time Up and Go test(Change from baseline The Time Up and Go test time at 12 weeks.)
- The 6-Minute Walk Test(Change from baseline The 6-Minute Walk Test scores at 12 weeks.)
- Pulmonary function (Forced Expiratory Volume in one second; FEV1)(Change from baseline FEV1 at 12 weeks.)
- Respiratory muscle strength(Change from baseline respiratory muscle strength at 12 weeks.)
- The Chair Sit and Reach Test(Change from baseline The Chair Sit and Reach Test scores at 12 weeks.)
- The Arm Curl test(Change from baseline The Arm Curl test scores at 12 weeks.)
- The 2-Minute Step Test(Change from baseline The 2-Minute Step Test scores at 12 weeks.)
研究者
Wannaporn Tongtako, Ph.D.
Principal investigator
Chulalongkorn University