Water-based exercise in people with stable coronary heart disease (Study A)

Not Applicable

• Conditions: Coronary heart disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12616000113459
• Lead Sponsor: Curtin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-02
• Last Update Posted: 21 June 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

* Stable, documented coronary heart disease and be at least 6 months following a myocardial infarction, coronary artery bypass graft or percutaneous coronary intervention
*Have been taking stable medical therapy for the last 2 months
*Be able to participate in exercise training 3 days per week and organise their own transport

Exclusion Criteria

*Renal impairment, hepatic impairment, proteinurea or hyperuricaemia
*Left ventricle ejection fraction below 45%
*Musculoskeletal or neurological condition or injury that precludes exercise training
*Any current or recent neoplasms or cancer treatment
*Current smokers
*Premenopausal females (due to the potential effects of hormonal cycle on vascular assessment)
*Currently participating in a formal exercise program at least 3 times per week, or have done so in the last 6 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral blood flow (CBF) will be assessed using a 2MHz, pulsed ST3 transcranial ultrasound system (Spencer Technologies, Seattle, Washington, USA) to determine the velocity of the middle cerebral artery. [At the end of each intensity of exercise (40% and 60% of Vo2peak, for both immersed and dry exercise).]

Secondary Outcome Measures

Name	Time	Method
Brachial artery diameter and blood flow will be assessed using ultrasound and analysed with custom designed software. The results of blood flow and diameter readings will be interpreted together to examine endothelial function (composite measure). [At the end of each intensity of exercise (40% and 60% of Vo2peak, for both immersed and dry exercise).];Blood pressure will be measured using a Finomemter pro device and exported to software for analysis.[At the end of each intensity of exercise (40% and 60% of Vo2peak, for both immersed and dry exercise).];Heart rate will be measured by a heart rate monitor and by the finometer pro device[At the end of each intensity of exercise (40% and 60% of Vo2peak, for both immersed and dry exercise). <br>]