The Influence of HRV-changing Premedication on Hemodynamic Parameters After Spinal Anesthesia
Overview
- Phase
- N/A
- Intervention
- Midazolam
- Conditions
- Hemodynamics After Spinal Anesthesia
- Sponsor
- Medical University of Gdansk
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- hemodynamics after spinal anesthesia
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Blood pressure drop following spinal anesthesia is connected with sympathetic/parasympathetic activity which may be determinated by Heart Rate Variability (HRV) assessment. Sympathetic predomination expressed as LF/HF ratio above 2.5 is strongly connected with deeper blood pressure fall. As drugs given for premedication may have impact on HRV variables, the investigators would like to determine if pharmacological premedication may modify hemodynamic changes following spinal blockade. Two drugs will be compared - midazolam which is known to lead to increase in LF/HF ratio and morphine - opioid which provokes opposite effect.
Investigators
Eligibility Criteria
Inclusion Criteria
- •spinal blockade for elective surgery
Exclusion Criteria
- •contraindications for spinal anesthesia
- •hypertension
- •heart failure
- •chronic respiratory failure
- •hypersensitivity for midazolam or morphine
Arms & Interventions
Midazolam
intramuscular midazolam 15 mg given 30 minutes before spinal blockade performing
Intervention: Midazolam
Morphine
intramuscular morphine 10 mg given 30 minutes before spinal blockade performing
Intervention: Morphine hydrochloride; Midazolam
Outcomes
Primary Outcomes
hemodynamics after spinal anesthesia
Time Frame: one hour