Premedication and Haemodynamics After Spinal Anesthesia
Not Applicable
Completed
- Conditions
- Hemodynamics After Spinal Anesthesia
- Interventions
- Registration Number
- NCT01066247
- Lead Sponsor
- Medical University of Gdansk
- Brief Summary
Blood pressure drop following spinal anesthesia is connected with sympathetic/parasympathetic activity which may be determinated by Heart Rate Variability (HRV) assessment. Sympathetic predomination expressed as LF/HF ratio above 2.5 is strongly connected with deeper blood pressure fall. As drugs given for premedication may have impact on HRV variables, the investigators would like to determine if pharmacological premedication may modify hemodynamic changes following spinal blockade. Two drugs will be compared - midazolam which is known to lead to increase in LF/HF ratio and morphine - opioid which provokes opposite effect.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- spinal blockade for elective surgery
Exclusion Criteria
- contraindications for spinal anesthesia
- hypertension
- heart failure
- chronic respiratory failure
- hypersensitivity for midazolam or morphine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Midazolam Midazolam intramuscular midazolam 15 mg given 30 minutes before spinal blockade performing Morphine Morphine hydrochloride; Midazolam intramuscular morphine 10 mg given 30 minutes before spinal blockade performing
- Primary Outcome Measures
Name Time Method hemodynamics after spinal anesthesia one hour
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical University of Gdansk
🇵🇱Gdansk, Poland