跳至主要内容
临床试验/NCT05908266
NCT05908266招募中不适用

Behavioural Study of Reaching Control in Healthy Volunteers and Volunteers With Parkinson Disease in Dynamical Context

Université Catholique de Louvain1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
100
试验地点
1
主要终点
Applied forces

研究概览

简要总结

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 99 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Ability to perform the task (assessed during the experiment)

排除标准

  • Inability to perform the task (motor) or to understand the task requirements (cognitive)

结局指标

主要结局

Applied forces

时间窗: Measured during the entire experiment (an average of 4.5 years)

Forces applied by participants on the robotic handle. Units are Newtons

Kinematics

时间窗: Measured during the entire experiment (an average of 4.5 years)

Position of the handle as a function of time. Units are millimetres

Surface Electromyogram

时间窗: Measured during the entire experiment (an average of 4.5 years)

Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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