Flexible Reaching Control in Parkinson Disease

Recruiting

• Conditions: Parkinson Disease
• Interventions: Other: Reaching movements; Other: Disease Assessment

• Registration Number: NCT05908266
• Lead Sponsor: Université Catholique de Louvain

Brief Summary

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-01
• Study First Submitted: 2023-05-25
• Status Verified: 2023-06
• Study First Submitted QC: 2023-06-08
• Last Update Submitted: 2023-06-08
• Study First Posted: 2023-06-18
• Last Update Posted: 2023-06-18
• Primary Completion: 2027-10-31
• Study Completion: 2027-10-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Ability to perform the task (assessed during the experiment)

Exclusion Criteria

• Inability to perform the task (motor) or to understand the task requirements (cognitive)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Reaching movements	Healthy volunteers
PD	Disease Assessment	Patients with Parkinson disease
PD	Reaching movements	Patients with Parkinson disease

Primary Outcome Measures

Name	Time	Method
Applied forces	Measured during the entire experiment (an average of 4.5 years)	Forces applied by participants on the robotic handle. Units are Newtons
Kinematics	Measured during the entire experiment (an average of 4.5 years)	Position of the handle as a function of time. Units are millimetres
Surface Electromyogram	Measured during the entire experiment (an average of 4.5 years)	Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts

Trial Locations

Locations (1)

Université catholique de Louvain; 🇧🇪 Louvain-la-Neuve, Belgium