CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Completed

• Conditions: Stroke

• Registration Number: NCT00463281
• Lead Sponsor: Technische Universität Dresden

Brief Summary

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that

1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) \> area of reduced cerebral blood volume (CBV)) represent a significant proportion (\> 20%)of acute stroke patients and therefore are an important target group for future interventional studies

2. patients with a "tissue window" suffer an unfavourable outcome (\> 50 % mRS =\>4 at 3 months)if the occluded artery was not recanalized.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2007-04-19
• Study First Submitted QC: 2007-04-19
• Study First Posted: 2007-04-20
• Primary Completion: 2008-01
• Status Verified: 2009-01
• Study Completion: 2009-01
• Last Update Submitted: 2009-05-13
• Last Update Posted: 2009-05-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• ischemic anterior circulation stroke
• last seen normal < 12 hours
• stroke severity => 3 on the National Institute of Health Stroke Scale
• multimodal CT stroke protocol performed
• informed consent obtained

Exclusion Criteria

• premorbid modified Rankin Scale score > 3
• contraindications to contrast media application
• pregnancy or breast feeding
• subacute stroke > 50 % of MCA territory
• CT evidence of non-vascular cause of stroke symptoms

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
modified Rankin Scale scores 0-2	90 days

Trial Locations

Locations (1)

University of Dresden, Dept of Neurology; 🇩🇪 Dresden, Germany