Multimodal Investigation of Intracranial Clot Environment

Recruiting

• Conditions: Acute Ichemic Stroke; Brain Ischemia
• Interventions: Other: Analysis of the clot

• Registration Number: NCT04421326
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage

Detailed Description

It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.

Study Timeline

• Study First Submitted: 2020-05-28
• Study First Submitted QC: 2020-06-04
• Study First Posted: 2020-06-09
• Study Start: 2021-03-14
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-27
• Last Update Posted: 2024-05-29
• Primary Completion: 2025-06
• Study Completion: 2025-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with acute ischemic stroke	Analysis of the clot	Patients undergoing Mechanical Thrombectomy for large vessel occclusion with acute ischemic stroke

Primary Outcome Measures

Name	Time	Method
Metalloproteinase 9 quantification	60 months
Metalloproteinase 2 quantification	60 months

Secondary Outcome Measures

Name	Time	Method
Cytokines levels	60 months	Proteomic analysis of cytokines IL-1β, TNF-α, IL-6

Trial Locations

Locations (1)

University Hospital of Montpellier; 🇫🇷 Montpellier, France