Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

Not Applicable

Withdrawn

• Conditions: Mild Cognitive Impairment
• Interventions: Device: Active parietal; Device: Active frontal; Device: Sham

• Registration Number: NCT03446508
• Lead Sponsor: The University of Texas at Dallas

Brief Summary

This study is attempting to improve word finding and memory retrieval problems persons with mild cognitive impairment (MCI) may have.

Detailed Description

This study attempts to improve word finding and memory retrieval problems in persons with mild cognitive impairment (MCI). To remember and find words, the brain has to search for the correct memory and MCI can negatively affect this search. Studies have suggested that low level electrical stimulation of the memory retrieval circuit can improve memory recall. The purpose of this study is to find the exact influence of multi-electrode or High Definition transcranial Direct Current Stimulation (HD-tDCS) by targeting a frontal and a parietal brain area, and their roles in memory retrieval/word finding in MCI. By modulating ongoing activity in 6 sessions of HD-tDCS the study investigates whether HD-tDCS may be used as a way to improve memory retrieval/word finding evaluated by cognitive measures and electroencephalography (EEG) measures before the first session and after the last session of HD-tDCS with a follow-up session 1-month after the stimulation procedure.

Study Timeline

• Study Start: 2017-11-18
• Study First Submitted: 2018-01-22
• Study First Submitted QC: 2018-02-22
• Study First Posted: 2018-02-26
• Status Verified: 2022-01
• Primary Completion: 2022-01-25
• Study Completion: 2022-01-25
• Last Update Submitted: 2022-01-25
• Last Update Posted: 2022-02-08

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Age between 40 and 90
2. Capable of understanding and signing an informed consent
3. Experiencing severe memory problems

Exclusion Criteria

1. Severe organic co-morbidity
2. Pace maker / defibrillator
3. Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Active parietal	Active parietal	Active HD-tDCS
Active frontal	Active frontal	Active HD-tDCS
Sham control	Sham	Sham HD-tDCS

Primary Outcome Measures

Name	Time	Method
Memory retrieval/word finding assessment.	Baseline (before the first HD-tDCS session), immediate post (immediately after the last HD-tDCS session) and 1 month follow up (1 month after the last HD-tDCS session)	Changes in cognitive performance are compared between the 3 groups to investigate the influence of HD-tDCS on memory retrieval/word finding.

Secondary Outcome Measures

Name	Time	Method
Electroencephalography (EEG).	Baseline (before the first HD-tDCS session), immediate post (immediately after the last HD-tDCS session) and 1 month follow up (1 month after the last HD-tDCS session)	Brain activity is recorded with electroencephalography (EEG) and is compared between the 3 groups to investigate the influence of HD-tDCS on memory retrieval/word finding.

Trial Locations

Locations (1)

University of Texas at Dallas; 🇺🇸 Richardson, Texas, United States