Coronary artery grafting in high risk patients randomised to off-pump or on-pump surgery

Completed

• Conditions: Coronary heart disease; Circulatory System; Chronic ischaemic heart disease

• Registration Number: ISRCTN29161170
• Lead Sponsor: niversity of Oxford (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10-31
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5420

Inclusion Criteria

Current information as of 05/03/2010:
Patients having isolated CABG surgery will be eligible if they satisfy the following criteria:
1. Euroscore =5
2. Non-emergency surgery
3. Operation to be carried out via a median sternotomy
4. Written informed patient consent

Initial information at time of registration:
Patients having isolated CABG surgery will be eligible if they satisfy the following criteria:
1. Patients (male or female) aged greater than or equal to 70 years
2. Male patients under 70 years of age with moderate or poor left ventricular function (ejection fraction less than 50%)
3. Euroscore greater than or equal to 5
4. Non-emergency surgery
5. Operation to be carried out via a median sternotomy
6. Written informed patient consent

Exclusion Criteria

Current information as of 05/03/2010:
1. Euroscore <5
2. Emergency operation (immediate revascularisation for haemodynamic instability)
3. Concomitant cardiac procedure with CABG
4. Operation to be carried out via an incision other than a median sternotomy (e.g. anterolateral left thoracotomy)
5. Known contraindication to ONCABG or OPCABG (e.g. calcified aorta, calcified coronaries, small target vessels)

Initial information at time of registration:
1. Male patient under 70 years of age with good left ventricular function (ejection fraction greater than 50%)
2. Euroscore less than 5
3. Emergency operation (immediate revascularisation for haemodynamic instability)
4. Concomitant cardiac procedure with CABG
5. Operation to be carried out via an incision other than a median sternotomy (e.g. anterolateral left thoracotomy)
6. Contraindication to ONCABG or OPCABG (e.g. calcified aorta, intramuscular left anterior descending [LAD], calcified coronaries, small target vessels)

Study & Design

• Study Type: Interventional
• Study Design: Not specified