BDNF Level and val66met Polymorphism of Brain Derived Neurotropic Factor Gene in Patients With T2DM and Depression

Not Applicable

Completed

• Conditions: Diabetes Mellitus; Depression
• Interventions: Other: Questionare

• Registration Number: NCT05526131
• Lead Sponsor: Kasr El Aini Hospital

Brief Summary

This study aimed to evaluate the relation between the levels of (Brain Derived Neurotropic Factor) BDNF and val66met polymorphism of BDNF gene, and the presence of depression in type 2 diabetes. In addition to studying the relationship between BDNF level and val66met polymorphism of its gene and assessing relation between BDNF level and obesity.

Detailed Description

The study included 88 type 2 diabetic patients, which are further divided into two groups; depressed and non-depressed. Depression was assessed by Hamilton Depression Rating Scale (HAM-D) and structured clinical interview for DSM-IV Axis disorder (SCID-I) for diagnosing depression and exclusion of other psychiatric disorders. Genotyping was performed by using Real Time-PCR (TaqMan probes).

Study Timeline

• Study Start: 2021-02-17
• Primary Completion: 2021-09-20
• Study Completion: 2021-10-23
• Status Verified: 2022-08
• Study First Submitted: 2022-08-31
• Study First Submitted QC: 2022-09-01
• Last Update Submitted: 2022-09-01
• Study First Posted: 2022-09-02
• Last Update Posted: 2022-09-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with type 2 Diabetes Mellitus and depression	Questionare	This arm includes patients with type 2 diabetes mellitus that were diagnosed with depression using structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders.
Patients with type 2 Diabetes Mellitus and no depression	Questionare	This arm includes patients with type 2 diabetes mellitus where depression was ruled out using structured clinical interview for DSM-IV Axis disorder (SCID-I) and Hamilton Depression Rating Scale (HAM-D) for diagnosing depression and exclusion of other psychiatric disorders.

Primary Outcome Measures

Name	Time	Method
val66met polymorphism of BDNF gene	1 day (At the time of recruitment)	Measurement of val66met polymorphism of BDNF gene
BDNF level in blood	1 day (At the time of recruitment)	Measurement of the level of BDNF in blood

Trial Locations

Locations (1)

Cairo university hospitals; 🇪🇬 Cairo, Egypt