The resilient brain of preterm born childre

Recruiting

Conditions: Hersenactiviteit na acute stress.
Stress-related brain acitivity
10037173

Registration Number: NL-OMON48425

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 160

Inclusion Criteria

Extremely preterm born children
- Gestational age <28 weeks
- Age at assessment 8-11 years., Healthy controls
- Gestational age >38 weeks
- Age and gender at assessment are matched to an extremely preterm born child
included in the study.

Exclusion Criteria

Extremely preterm born children
- Major chromosomal and/or congenital anomalies.
- Current psychiatric disorder (i.e., as indicated by a current DSM-V diagnosis)
- Ferromagnetic objects inside the body (see MRI screening)
- Claustrophobia
- Use of medication known to influence HPA-axis functioning (i.e.,
corticosteroid medication)
- Parents are not willing to provide informed consent
- Parents are not allowing unexpected findings to be reported to themselves or
their general practitioner(s)., Healthy controls
In addition to the previously mentioned exclusion criteria for preterm born
children, the following criteria will disqualify prospective control
participants from participating:
- Relative of the included preterm born child.
*

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Brain activity measured with fMRI during emotion processing (i.e., IAPS),<br /><br>behavioural control (i.e., SSAT), and rest, following acute stress in premature<br /><br>born children compared to full-term born children.<br /><br>- Factors determining variability underlying brain activity following acute<br /><br>stress in extremely preterm born children, such as coping strategies, life<br /><br>events, and personality, amongst others.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To study basal and stress-induced changes in hormonal levels (i.e., cortisol,<br /><br>alpha-amalyse), heart-rate, and perceived stress (i.e., VAS) in preterm born<br /><br>children compared to healthy controls. </p><br>