The SYMPTOM Study: factors influencing patient appraisal of symptoms

Not Applicable

Completed

• Conditions: Topic: National Cancer Research Network, Primary Care Research Network for England; Subtopic: Colorectal Cancer, Upper Gastro-Intestinal Cancer, Lung Cancer, Not Assigned; Disease: Colon, Lung (small cell), Lung (non-small cell), Pancreas, Rectum, All Diseases; Cancer

• Registration Number: ISRCTN47493581
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust and University of Cambridge (UK)

Brief Summary

2014 results in: https://www.ncbi.nlm.nih.gov/pubmed/25553249 2015 results in: https://www.ncbi.nlm.nih.gov/pubmed/25734397 2015 results in: https://www.ncbi.nlm.nih.gov/pubmed/26453591 2016 results in: https://www.ncbi.nlm.nih.gov/pubmed/27490803 2016 results in: https://www.ncbi.nlm.nih.gov/pubmed/28404200 2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28871013

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-03-03
• Study Completion: 2012-12-31
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 7000

Inclusion Criteria

Respiratory symptoms:
1. Aged over 40 years, either sex
2. Persistent or changed cough
3. Change of breathlessness
4. Chest pain (intermittent, worse when breathing or coughing)
5. Coughing up blood-stained phlegm (haemoptysis)
6. GP expressed concern about possibility of cancer

Gastrointestinal symptoms:
1. Aged over 40 years, either sex
2. Change in bowel habit
3. Blood in stool
4. Abdominal pain with weight loss
5. Abdominal mass
6. Anaemia
7. GP expressed concern about possibility of cancer

Exclusion Criteria

Respiratory symptoms:
1. Review of established diagnosis where there is no cancer concern
2. Previous lung or ENT cancer

Gastrointestinal symptoms:
1. Review of established diagnosis where there is no cancer concern
2. Previous gastrointestinal (GI) cancer
3. Chronic alcohol abuse (to exclude chronic pancreatitis)
4. Known infective diarrhoea (e.g., after recent foreign travel)
5. Abdominal pain in the absence of weight loss
6. Dyspepsia
7. Upper abdominal pain where dyspepsia is a significant symptom

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of patient and symptom factors associated with later presentation to health care, measured at 24 months (end of study)

Secondary Outcome Measures

Name	Time	Method
<br> 1. Association of delay in presentation of symptoms with stage at diagnosis, measured at 24 months (end of study)<br> 2. Understanding patient interpretation of symptoms and the language used by patients, measured at 24 months (end of study)<br>