Diagnosis of Endocrine Dysfunctions in Covid-19 : Explorations of the Plasma Renin and Aldosterone Levels in Patients With Covid-19 Infection.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Plasma aldosterone levels
研究概览
简要总结
As observed with SARS-CoV responsible for SARS 2003, the new coronarovirus SARS-CoV-2 uses the angiotensin converting enzyme type 2 (ACE2) as cellular receptor to infect cells. The renin aldosterone angiostensin system (RAAS) has known effects in the lungs: some receptors are pro-inflammatory, others are anti-inflammatory. Thus the deregulation of the RAAS induced by the SARS-CoV-2 could explain the inflammatory response of Covid-19 infection and be a modulator of the severity of its course.
Furthermore, the SARS 2003 experience suggests that there may be others endocrine involvment, particularly an failure on the hypothalamus-pituitary and adrenal axis. Indeeed, cases of hypocorticism and hypothyroidism of central origin were described.
Altogether, the endocrine system might play a role both in the pathophysiology of Covid-19 infection and in the activity and severity of the disease.
In this study, the investigators proposed to explore endocrine functions on biological samples in a series of patients admitted for Covid-19 in our clinic.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Plasma aldosterone levels
时间窗: 1 day (at inclusion)
Plasma aldosterone levels
Plasma renin levels
时间窗: 1 day (at inclusion)
Plasma renin levels
次要结局
- Plasma aldosterone level(1 day (at the end of hospitalization))
- Maximum severity of Covid-19 infection(1 day (at inclusion))
- Plasma DHEA level(1 day (at inclusion))
- Plasma FSH level(1 day (at inclusion))
- Clinical characteristics(1 day)
- covid-19 infection severity(1 day (at inclusion))
- Plasma ACTH level(1 day (at inclusion))
- Plasma T3l level(1 day (at inclusion))
- Plasma LH level(1 day (at the end of hospitalization))
- Plasma cortisol level(1 day (at the end of hospitalization))
- Plasma estradiol (female) or testosterone (male) level(1 day (at inclusion))
- type of treatments(1 day)
- radiological characteristics(1 day)