Extended metabolic phenotyping of subjects undergoing bariatric surgery
- Conditions
- 'obesity''overweight'100184241001799810057166
- Registration Number
- NL-OMON36449
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 1200
Inclusion Criteria
Scheduled for malabsorptive bariatric surgery in one of the participating centers
Aged 18-65 years
Stable weight for 3 months prior to inclusion
Exclusion Criteria
Major bleeding disorder
Renal insufficiency (creatinine > 150 umol/L), liver enzymes > 3x ULN
Unable to read or speak the Dutch language
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Predictive value of pre-operative variables to weight loss expressed as<br /><br>percentage excess weight loss, reversal of metabolic complications of obesity,<br /><br>quality of life and postoperative complications; eating behavior and quality of<br /><br>life before and after bariatric surgery; pre-operative metabolic variables in<br /><br>plasma and tissue (adipose tissue and liver) correlated with metabolic health<br /><br>c.q. markers of the metabolic syndrome</p><br>
- Secondary Outcome Measures
Name Time Method <p>Prevalence of hypertension and metabolic complications of obesity before and<br /><br>after bariatric surgery; association of eating behavior with polymorphisms<br /><br>involved in appetite regulation and markers of pre-operative metabolic health.</p><br>