itgebreide analyse van de stofwisseling van patiënten die bariatrische chirurgie ondergaan.
Recruiting
- Conditions
- obesity, insulin resistance, metabolic syndrome, obesitas, insulineresistentie, metabool syndroom
- Registration Number
- NL-OMON21979
- Lead Sponsor
- Academic Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1200
Inclusion Criteria
1. Scheduled for malabsorptive bariatric surgery;
2. Age 18-65 years;
Exclusion Criteria
1. Major bleeding disorder;
2. Renal insufficiency (creatinine > 150 umol/L), liver enzymes > 3x ULN;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To identify predictive variables correlated with percentage excess weight loss (EWL), reversal of metabolic complications of obesity, quality of life after bariatric surgery and postoperative complications (special focus on inflammatory pathways and eating behavior);<br /><br>2. To identify metabolic variables (using a metabolomics approach) in plasma and tissue (adipose tissue as well as liver) correlated with metabolic health c.q. markers of the metabolic syndrome.
- Secondary Outcome Measures
Name Time Method 1. To assess the prevalence of hypertension and metabolic complications of obesity in obese patients scheduled for bariatric surgery;<br /><br>2. To study the association of eating behavior with possible polymorphisms involved in appetite regulation and with markers of metabolic health.