Furanocoumarin metabolites as dietary biomarkers of grapefruit consumptio

Completed

• Conditions: Concentration of furanocoumarin metabolites in urine; Not Applicable

• Registration Number: ISRCTN78596053
• Lead Sponsor: Centros de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn) (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05-13
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

Healthy adult males aged 20-35 years

Exclusion Criteria

1. Previous history of cardiovascular disease (ischemic heart disease - angina or recent or old myocardial infarction, cerebral vascular accident, or peripheral vascular disease)
2. Homeostatic disorders
3. Any several chronic diseases
4. Hypertension or dyslipidemia
5. Smoking subjects
6. Alcoholism
7. Other toxic abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Furanocoumarin metabolites will be identified through liquid chromatography coupled to Orbitrap mass spectrometry. Concentrations of furanocoumarins will be determined by liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). These determinations will be carried out in first morning urine samples collected the day before the first intervention and in the morning following each intervention.