Pain and Schizophrenia

Not Applicable

Terminated

• Conditions: Pain; Schizophrenia
• Interventions: Other: unpleasant stimuli

• Registration Number: NCT01244542
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The aim of the investigators project is to explore the mechanisms of pain insensitivity in patients with schizophrenia, in order to prevent its invalidating consequences. The investigators will couple methods of experimental psychology with EEG and blood samplings, in order to distinguish the role of non-painful perception, attention, aversive effects, and pain expression, and the investigators will explore an original neurobiological hypothesis regarding the activation of opioid receptors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-11-17
• Study First Submitted QC: 2010-11-18
• Study First Posted: 2010-11-19
• Study Start: 2011-08
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Status Verified: 2017-09
• Last Update Submitted: 2017-10-04
• Last Update Posted: 2017-10-05

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

• Patients with schizophrenia (criteria DSM IV) or healthy controls matched with patients on age, sex and education level
• 18-55 years old

Exclusion Criteria

• Past history affecting CNS
• Intake of psychotropic drugs, except for patients
• Metabolic disorder affecting sensory processing (diabetes)
• Intake of benzodiazepines

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with schizophrenia	unpleasant stimuli	-
Healthy controls	unpleasant stimuli	controls matched with patients on age, sex and education level

Primary Outcome Measures

Name	Time	Method
Unpleasant stimuli	during experimental session	emotional pictures

Trial Locations

Locations (5)

Service de Psychiatrie Adulte2, Place Saint-Jacques - ZA 481, Centre Hospitalier Saint-Jacques; 🇫🇷 Besançon Cedex, France

Service de Psychiatrie Adulte, Secteur G11, Centre Hospitalier de Erstein, 13 route de Krafft; 🇫🇷 Erstein Cedex, France

Centre d'évaluation et de traitement de la douleur, Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg Cedex, France

Centre d'Investigation Clinique - Hôpitaux Universitares de Strasbourg; 🇫🇷 Strasbourg Cedex, France

Service de Psychiatrie - Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg cedex, France