Effect of hypoglycemic agents on ischemic preconditioning in patients with diabetes and symptomatic coronary artery disease
- Conditions
- Type 2 diabetes / coronary artery diseaseCirculatory System
- Registration Number
- ISRCTN62282580
- Lead Sponsor
- Zerbini Foundation (Fundação Zerbini) (Brazil)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 206
1. Patients with type 2 diabetes mellitus under adequate drug treatment and no insulin dependence
2. A positive test for myocardial ischemia during a previous treadmill exercise test (horizontal or downsloping ST-segment depression >=1.0 mm)
3. Multivessel coronary disease confirmed by coronary angiography, and coronary disease with an internal diameter reduction of >=70% of at least two major coronary branches
4. Preserved left ventricular function confirmed by transthoracic echodopplercardiography
1. Myocardial infarction during the last 3 month
2. Severely impaired myocardial function (ejection fraction <45%)
3. ECG changes that could interfere with the interpretation of the ST segment
4. Impaired hepatic or renal function
5. Progressive fatal disease
6. Mental disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We will evaluate the effect of two hypoglycemic drugs on ischemic preconditioning by two sequential treadmill exercise tests (warm-up phenomenon). The warm-up phenomenon will be analysed by following parameters:<br>1. The time to onset of 1.0-mm ST-segment depression (the horizontal or downsloping ST-segment depressions were considered) <br>2. Rate pressure product (heart rate x systolic blood pressure) at the onset of 1.0-mm ST-segment depression
- Secondary Outcome Measures
Name Time Method o secondary outcome measures