Studies on the effect of hyperglycemia on the structure of the fibrin-gel and on the glycosylation of fibrin , and in what way the use of acetylsalicylic acid may interfere with this effect. - Effect of ASA on the fibrin-gel.
- Conditions
- Patients with type 1 diabetes, not on ASA for the last 6 months, without a history of bleeding disorder and with a normal trobocyte count.
- Registration Number
- EUCTR2005-005723-34-SE
- Lead Sponsor
- Dept of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Patients with type 1 diabetes with a HbA1c <6,5% and above 8% respectivelöy
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
see above
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To find out of ASA may interfere with the effect of hyperglycemia on the porosity of the fibrtin-gel (in vitro).;Secondary Objective: To find out if there is an interaction between glucose and ASA on the glycosylation/ acetylation of fibrinogen, and further if the magniotude of chronic hyperglycemia (as evaluated by the HbA1c level) or the dose of ASA ( 75 or 300 mg) is of importance.;Primary end point(s): Fibrin gel porosity
- Secondary Outcome Measures
Name Time Method