Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock

Completed

• Conditions: Meningococcal sepsis; Infections and Infestations; Meningococcal infection

• Registration Number: ISRCTN68283215
• Lead Sponsor: Erasmus Medical Centre, Sophia Children?s Hospital (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07-07
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

The study population consisted of previously healthy children admitted to the Pediatric Intensive Care Unit (PICU) of the Erasmus Medical Centre - Sophia Children?s Hospital between October 1997 and May 2004, suffering from meningococcal sepsis, i.e. sepsis with petechiae/purpura

Exclusion Criteria

1. Pre-existing endocrine or chromosomal abnormalities
2. Radiation or chemotherapy within the previous 6 months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Blood glucose levels <br>2. Plasma levels of <br>2.1. insulin <br>2.2. C-peptide<br>2.3. cortisol<br>2.4. cytokines<br>2.5. C-reactive protein (CRP)<br>2.6. cytokines<br>Measured on admission, and at 24 and 48 hours.