Comparison Between Spontaneous Breathing Trials Through Pressure-Support Ventilation or "T" Tube in the Weaning of Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Weaning of Mechanical Ventilation
- Sponsor
- Hospital Nossa Senhora da Conceicao
- Enrollment
- 190
- Locations
- 1
- Primary Endpoint
- Days Spent on Mechanical Ventilation
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Weaning of mechanical ventilation (MV) is an essential part in management of patients with Chronic Obstructive Pulmonary Disease (COPD) when critically ill. The best strategy to be used has not been established.
Objective: To compare the Spontaneous Breathing Trial (SBT) in Pressure Support Ventilation with SBT through "T" tube in weaning of MV in patients with COPD.
Design: Randomized Clinical Trial. Methods: This study will include patients with COPD, admitted to the Intensive Care Unit of Hospital Nossa Senhora da Conceição, undergoing MV for at least 48 hours. When considered by the care team ready for SBT, they will be randomized to one of the following strategies: SBT in Pressure Support or SBT through "T" Tube. The primary endpoint of this study will be the reduction in the days spent on MV. Other outcomes measured will be mortality, extubation and success rate, time to weaning of MV, length of ICU stay and incidence of tracheostomy.
Investigators
Jose Augusto Santos Pellegrini
Principal Investigator
Hospital Nossa Senhora da Conceicao
Eligibility Criteria
Inclusion Criteria
- •COPD patients admitted to our ICU for Acute Respiratory Failure, submitted to Mechanical Ventilation for at least 48 hours
- •18 years or older
Exclusion Criteria
- •Tracheostomy
- •Younger than 18 years
- •Refuse to give informed consent
- •Individuals who are already enrolled in another clinical trial
Outcomes
Primary Outcomes
Days Spent on Mechanical Ventilation
Time Frame: Participants will be followed for the duration of ICU stay, an expected average of 2 weeks
Secondary Outcomes
- Mortality(Participants will be followed for the duration of hospital stay, an expected average of 4 weeks)
- Extubation success rate(Participants will be followed for the duration of ICU stay, an expected average of 4 weeks)