Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Serum biomarkers of joint function
研究概览
简要总结
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with documented multi-joint/knee arthritis
排除标准
- •inability to give informed consent
- •pregnancy or lactation
- •planned knee replacement surgery
- •allergy or contraindication to berries
- •recent trauma of the knee responsible of the symptomatic knee
- •intra-articular injection in the target knee/hip in the last 3 months
- •oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
- •use of berry extracts in the last 3 months
- •special diets
- •cancer treatment
- •bone diseases
研究组 & 干预措施
Wild blueberries
25g freeze-dried wild blueberries daily for 12 weeks
干预措施: Wild blueberry (Dietary Supplement)
Placebo
Placebo powder free from polyphenols matched for calories
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Serum biomarkers of joint function
时间窗: 12 weeks
Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.
次要结局
- Gut microbiome(12 weeks)
研究者
Arpita Basu
Associate Professor
University of Nevada, Las Vegas