Blueberry consumption and metabolic syndrome

Not Applicable

• Conditions: Metabolic syndrome; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN47717032
• Lead Sponsor: niversity of Milan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-03
• Last Update Posted: 27 March 2023
• Study Completion: 2024-01-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

1. Women and men
2. Aged 40-65 years
3. Body mass index 25-30 kg/m²
4. Waist circumference =102 cm in men and =88 cm in women
5. High density lipoprotein cholesterol < 1.04 mmol/l in men and <1.30 mmol/l in women
6. Serum triglycerides =1.7 mmol/l or treatment with triglycerides-lowering drugs
7. Systolic blood pressure =130 mmHg or diastolic blood pressure =85 mmHg or treatment with blood pressure lowering drugs
8. Serum glucose =6.1 mmol/l or treatment with blood glucose-lowering drugs
9. No smokers

Exclusion Criteria

1. Obesity
2. Uncontrolled diabetes
3. Primary hypercholesterolemia
4. Dysthyroidism
5. Liver and renal disease
6. Gastrointestinal disorders
7. Antibiotic treatment
8. Use of supplements
9. Impaired cognitive function
10. Smokers
11. Allergy to blueberry and their products
12. Vegetarian, vegans, macrobiotic

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Acute study: improvement of vascular function measured as reactive hyperemia index (by EndPAT2000) at baseline and 2 hours after the intake of blueberry or placebo treatments<br><br> Chronic study: improvement of vascular function measured as reactive hyperemia index (by EndPAT2000) at baseline and after 8-week treatment with blueberry or placebo<br>