Randomised placebo-controlled trial of oral doxycycline to reduce recurrent trachomatous trichiasis

Not Applicable

Recruiting

• Conditions: trachomatous trichiasis; Surgery; Trachomatous trichiasis

• Registration Number: PACTR201512001370307
• Lead Sponsor: ondon School of Hygiene & Tropical Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-11-29
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

1.Trachomatous Trichiasis with tarsal conjunctival scarring
2.Adults (>18 years of age)
3.Agree to be randomly allocated to receive doxycycline or placebo following surgery
4.Agree to re-examination at one week, one, six and twelve months after surgery

Exclusion Criteria

1.Age less than 18 years
2.Pregnant or breast-feeding women
3.Previous eyelid surgery
4.Medically unfit, BP systolic >170, diastolic >110
5.People with known history of hypersensitivity/allergy to Doxycycline or Tetracycline
6.Presence of contra-indication to doxycycline usage
oTaking warfarin
oTaking sulphonylurea based medication for diabetes
oPre-existing known liver or renal impairment
oMyasthenia gravis
7.Patients with trichiasis from other eyelid pathologies, such as:
oBlepharitis
oSteven Johnson syndrome
oBurn
oTrauma
oEyelid muscle laxity due to aging
oHerpes zoster
oOcular cicatricial pemphigoid

Study & Design

• Study Type: Interventional
• Study Design: Not specified