Automated Minimization of Ventilator Energy to Improve Lung-Protective Ventilatio
Phase 4
- Conditions
- Invasive mechanical ventilation
- Registration Number
- DRKS00013540
- Lead Sponsor
- niversitätsklinikum Schleswig-Holstein
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Patients on invasive mechanical Ventilation on intensive care units
- arterial line for invasive blood pressure measurement present
- Age > 18 years
- written informed consent
Exclusion Criteria
- expiratory time constant > 1.5 s
- PaO2/FiO2 Ratio < 100 mmHg
- arterial pH < 7.2 despite optimization of Ventilator Settings by treating ICU physician
- arterial CO2 > 70 mmHg despite optimization of Ventilator Settings by treating ICU physician
- acute severe hemodynamic instability (mean arterial pressure < 65 mmHg despite adequate therapy with fluid and/or vasopressors OR heart rate > 150/min OR heart rate < 40/min)
- high frequency oscillatory Ventilation
- spontaneous breathing activity
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tidal volume in ml per kg predicted body weight after one hour of mechanical ventilation with the respective mode (AVM or AVM2)
- Secondary Outcome Measures
Name Time Method - Driving pressure (Difference between airway plateau pressure and end-expiratory airway pressure, cmH2O)<br>- power of breathing (J/min)<br>- arterial partial pressure of oxygen (mmHg)<br>- arterial partial pressure of carbon dioxide (mmHg)<br>- pH<br>- alveolar Minute Ventilation (l/min, calculated as (tidal volume - Serial dead space volume) * respiratory rate)<br>- mean airway pressure (cmH2O)<br>- mean arterial pressure (mmHg) <br>- heart rate (1/min, ECG)<br>