Lenalidomide Based Immunotherapy in the Treatment of DLBCL
- Conditions
- Diffuse Large B Cell Lymphoma
- Registration Number
- NCT03715296
- Lead Sponsor
- Ruijin Hospital
- Brief Summary
This study is to evaluate the efficacy related molecular biomarker of Lenalidomide plus RCHOP or RICE in the treatment of de novo or Refractory and Relapsed DLBCL patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Histologically diagnosed as diffuse large b-cell lymphoma and may provide a desirable lymph node tissue sample (10 paraffin sections or rolls) or lymph node biopsy sample (15 paraffin sections or rolls)
Previously treated with Lenalidomide plus RCHOP regimen in de novo DLBCL or Lenalidomide plus RICE regimen in relapse refractory DLBCL.
No history of stem cell transplantation.
Written informed consent.
Chemotherapy or large field radiotherapy within 3 weeks prior to entering the study.
Clinically significant active infection.
Impaired liver, renal or other organ function not caused by lymphoma, which will interfere with the treatment schedule.
Any significant medical or psychiatric condition that might prevent the patient from complying with all study procedures.
Subject has ≥grade 2 peripheral neuropathy or grade 1 with pain within 14 days before enrollment.
Patients who are pregnant or breast-feeding.
HIV infection.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Complete response rate 12 weeks
- Secondary Outcome Measures
Name Time Method Overall survival rate 1 year Overall response rate 12 weeks Progression free survival rate 1 year
Trial Locations
- Locations (1)
Ruijin hospital
🇨🇳Shanghai, Shanghai, China