Prevalence of Clopidogrel (Plavix) Resistance in Hemodialysis Patients
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT01865890
- Lead Sponsor
- Northwell Health
- Brief Summary
The investigators are trying to find out if Clopidogrel (Plavix) is as effective in hemodialysis patients as in patients not hemodialysed.
- Detailed Description
Cardiovascular disease is very frequent in hemodialysis patients. Lot of hemodialysis patients are on Clopidogrel (plavix). Their is some evidence that clopidogrel is not effective in hemodialysis as it is effective in patient without kidney problem.
VerifyNow plavix is a machine that measure the ability of the blood to clot after giving plavix.
We will collect blood from hemodialysis patients on plavix and check the ability of their blood to clot and thus indirectly measuring the efficacy of Plavix.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- All patients on hemodialysis taking Plavix
- known to have bleeding disorder
- Severely anemic with hemoglobin level (Hb) < 10g/dl
- Low Platelets < 10000
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence Of Plavix resistance 1 day ( one study visit) Plavix resistance is reported using the PRU values given by the VerifyNow machine. PRU is P2Y12 Reaction Units which is correlated with platelet aggregation.
- Secondary Outcome Measures
Name Time Method assess the risk factors for plavix resistance in the hemodialysis population 1 day (one study visit) Coronary Artery Disease (CAD) is very common in dialysis patients. Treatment of CAD include medical therapy, stent placement and surgery. Since Plavix is a medication that is commonly used after stent placement, we would like to assess the efficacy of this medication in this patient population.
Trial Locations
- Locations (1)
Staten Island University Hospital
🇺🇸Staten Island, New York, United States