The effect of left ventricular filling pressure on pulmonary clearance of free radical loaded white blood cells and platelets in congestive heart failure patients before and after biventricular pacing

Completed

• Conditions: Decompensatio Cordis; Heart failure; 10019280

• Registration Number: NL-OMON31660
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

·Chronic congestive heart failure patients of all ages selected for biventricular pacemaker implantation for resynchronization therapy
·Dyspnoe NYHA class III and IV
·Optimal and constant heart failure treatment according to the ESC guidelines

Exclusion Criteria

·Renal failure (creatinine >1.70 mg/dl)
·Signs of infection or inflammation

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>·Oxidative stress: cytosolic and mitochondrial FR<br /><br>Bloodsamples are incubated with a fluorescent CM-DCF probe, which detects<br /><br>cytosolic FR, or with a Mito-FR probe, which detects mitochondrial FR.<br /><br>WBCs and platelets with significant fluorescence are identified by FACS and<br /><br>reported relative to their total number.<br /><br>·Number of (apoptotic) endothelial (progenitor) cells<br /><br>LV filling pressure determined by invasive measurement at the time of<br /><br>biventricular pacemaker implantation</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>see figure 2 en pag. 16 protocol</p><br>