Prognostic role of D-Dimer and Coagulation parameters in hospitalized COVID-19 patients

The study is prospective and will take place in the Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur ,Chennai between March 2021 and March 2023 after obtaining ethical clearance. It aims to evaluate the prognostic role of D-Dimer with illness severity. We also aim to observe the coagulation parameters (PT, PTT and INR) in patients with elevated D-Dimer and assess its correlation with complications and outcome. The identification of effective laboratory biomarkers capable of triaging patients with COVID-19 infection is very necessary taking into account the unpredictable course of the disease. Studies have shown a significant relation between D-Dimer levels and disease progression. Using the pre-structured proforma, patient’s clinical and laboratory data are collected and analysed after getting their consent. D-dimer values, course in hospital - oxygen requirement , drugs used with dosage, complications or adverse events that have occurred will all be recorded and statistical analysis will be done to correlate the two. The results of our study will help prompt triaging of the high risk patients and help rethink our treatment approach.