Small fibre neuropathy: aetiology, diagnosis and natural course An observational cohort study

• Conditions: painful neuropathy; small diameter nerve fibre neuropathy; 10034606

• Registration Number: NL-OMON30382
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

1. Age 18 years or older
2. Clinically suspected small fibre neuropathy
3. Normal results of standard nerve-conduction studies or only minor abnormalities not compatible with polyneuropathy

Exclusion Criteria

1. Age under 18 years
2. Symptoms and signs indicating large nerve fibre involvement
3. Nerve conduction studies compatible with polyneuropathy
4. Pre-existent vascular insufficiency, confirmed by echo doppler or a history of ulcus cruris

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>If patients are eligible they will undergo the following baseline<br /><br>investigations: various questionnaires, a general physical and neurological<br /><br>examination, extensive laboratory tests, chest radiograph, the short form QST<br /><br>protocol and a skin biopsy. These investigations are repeated at one and/or two<br /><br>years of follow-up. The results will be compared with eachother.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>