Diagnosing small fiber neuropathy in sarcoidosis patients using corneal confocal microscopy
Completed
- Conditions
- painfull neuropathy - autonomic neuropathy10038716
- Registration Number
- NL-OMON49119
- Lead Sponsor
- Sint Antonius Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
* Age 18-75 years
* Patients with sarcoidosis and SFN symptoms
* Patients with sarcoidosis and without SFN symptoms
Exclusion Criteria
* Ocular disease
* Ocular surgery
* Allergy to the anaesthetic or contents of eye gel
* Diseases with possible polyneuropathy
o Diabetes (type I & type II)
o Vitamin B12 deficiency
o Metabolic syndrome
o Impaired glucose intolerance
* Clinical relevant abnormal history of physical and/or mental health
* Pregnancy
* High alcohol intake
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Corneal CNFD, CNFD, CNFB and CNFT</p><br>
- Secondary Outcome Measures
Name Time Method <p>skin wrinkling grades: grade 0-4<br /><br>Electrochemical skin conductance<br /><br>Blood pressure (mmHg)<br /><br>SFNSL-score: <11 no SFN, >48 SFN confirmed<br /><br>Phenotypes: SFSCD, SFMNP, SFMWP and SFMAD</p><br>