Does a Flashlight Used to Detect Pet Biological Fluids on Human Skin and Other Surfaces Increase Gas Phase Nitric Oxide Levels?
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Change in Nitric Oxide during UV light exposure
研究概览
简要总结
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis. This study aims to help with the currently cumbersome and invasive procedures used to measure SNOs in the body. The proposed activities do not unnecessarily duplicate previous experiments.
详细描述
S-nitrosylation is the covalent attachment of a nitric oxide group to cystine thiol within a protein to form an S-nitrosothiol (SNO); it has diverse regulatory roles in all mammalian cells and thus operates as a fundamental mechanism for cellular signaling and accounts for a large part of nitric oxide activity. Though SNOs are relevant to many biological disciplines like neuronal, muscular, respiratory, and cardiovascular biology, currently there is no way to measure SNOs that is both easy to use in a clinical setting and accurate in detecting low concentrations; detection is challenging due to the labile nature of the molecules. Low or high concentrations of these molecules could be vital indicators of incoming dangerous issues in the body. A system to easily and accurately measure SNOs could prove useful in preventative treatments. Ultra Violet (UV) light can break SNOs and can be used to measure nitric oxide release, but this method is not fully developed and further research is needed on the potential effect for UV to measure nitric oxide release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 1 Day 至 75 Years(Child, Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult males or females age ≥ 1 day and ≤ 75 years at time of enrollment
排除标准
- •Subjects meeting the following criteria will be excluded:
- •Any chronic skin conditions.
- •Pregnant.
- •Subjects that are unable or unwilling to cooperate with specimen collection.
- •Subjects with diagnosis of any medical condition that in the investigator's opinion would make them unsuitable for study participation.
- •(for subjects ≥ 18) Subjects that lack the capacity to consent for themselves.
研究组 & 干预措施
Healthy Volunteers
Study will enroll to test the assay
干预措施: Alonefire SV003 10W 365nm UV Flashlight (Device)
结局指标
主要结局
Change in Nitric Oxide during UV light exposure
时间窗: 30 minutes
NO evolved during UV light exposure from the human ear lobe, hand or forehead.
次要结局
未报告次要终点
研究者
Nadzeya V Marozkina
Assistant Research Professor
Indiana University
