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临床试验/NCT04903535
NCT04903535Enrolling By Invitation不适用

Does a Flashlight Used to Detect Pet Biological Fluids on Human Skin and Other Surfaces Increase Gas Phase Nitric Oxide Levels?

Indiana University2 个研究点 分布在 1 个国家目标入组 150 人开始时间: 2021年5月10日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
Enrolling By Invitation
入组人数
150
试验地点
2
主要终点
Change in Nitric Oxide during UV light exposure

研究概览

简要总结

In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis. This study aims to help with the currently cumbersome and invasive procedures used to measure SNOs in the body. The proposed activities do not unnecessarily duplicate previous experiments.

详细描述

S-nitrosylation is the covalent attachment of a nitric oxide group to cystine thiol within a protein to form an S-nitrosothiol (SNO); it has diverse regulatory roles in all mammalian cells and thus operates as a fundamental mechanism for cellular signaling and accounts for a large part of nitric oxide activity. Though SNOs are relevant to many biological disciplines like neuronal, muscular, respiratory, and cardiovascular biology, currently there is no way to measure SNOs that is both easy to use in a clinical setting and accurate in detecting low concentrations; detection is challenging due to the labile nature of the molecules. Low or high concentrations of these molecules could be vital indicators of incoming dangerous issues in the body. A system to easily and accurately measure SNOs could prove useful in preventative treatments. Ultra Violet (UV) light can break SNOs and can be used to measure nitric oxide release, but this method is not fully developed and further research is needed on the potential effect for UV to measure nitric oxide release.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
1 Day 至 75 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult males or females age ≥ 1 day and ≤ 75 years at time of enrollment

排除标准

  • Subjects meeting the following criteria will be excluded:
  • Any chronic skin conditions.
  • Pregnant.
  • Subjects that are unable or unwilling to cooperate with specimen collection.
  • Subjects with diagnosis of any medical condition that in the investigator's opinion would make them unsuitable for study participation.
  • (for subjects ≥ 18) Subjects that lack the capacity to consent for themselves.

研究组 & 干预措施

Healthy Volunteers

Experimental

Study will enroll to test the assay

干预措施: Alonefire SV003 10W 365nm UV Flashlight (Device)

结局指标

主要结局

Change in Nitric Oxide during UV light exposure

时间窗: 30 minutes

NO evolved during UV light exposure from the human ear lobe, hand or forehead.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nadzeya V Marozkina

Assistant Research Professor

Indiana University

研究点 (2)

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