Serum Concentration of lgG in Patient With Acute Coronary Syndrome

Completed

• Conditions: Acute Coronary Syndrome

• Registration Number: NCT03394092
• Lead Sponsor: The First Affiliated Hospital of Dalian Medical University

Brief Summary

The aim of this study is to investigate the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction and the relationships between its change and prognosis.

Detailed Description

Immunoglobin G (IgG), a highly abundant glycoprotein in serum, is known to participate in blood immune responses.It has been an increasing interest in the analysis of the abnormal glycosylation of human lgG in healthy and disease states, such as autoimmune diseases and cancer.However, there is few relevant studies about the changes in glycopeptides of serum immunoglobulin G in patients with acute myocardial infarction. This study was performed for the frst timeto assess the quantitative changes of serum IgG glycosylation in patients with acute myocardial infarction and the relationships between its change and prognosis.

Study Timeline

• Study First Submitted: 2018-01-03
• Study First Submitted QC: 2018-01-03
• Study First Posted: 2018-01-09
• Study Start: 2018-01-15
• Primary Completion: 2019-01-15
• Status Verified: 2019-03
• Study Completion: 2019-03-01
• Last Update Submitted: 2019-03-17
• Last Update Posted: 2019-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• diagnosed as STEMI.

• with left ventricular ejection fraction（LVEF）>=45%
• written informed consents are obtained
• admitted within 24 hours after chest pain attacked

Exclusion Criteria

• complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy

  • complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
  • with acute or chronic infection, surgery or trauma in the last month
  • secondary hypertension, severe liver dysfunction,severe renal insufficiency
  • with abnormal thyroid function or allergy to iodine agent refusal to sign the informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum quantitative determination of lgG	12 months	Quantitative measurements the changes of serum IgG glycosylation by HPLC-MRM

Secondary Outcome Measures

Name	Time	Method
The changes of LVEF in two groups	12 months	Association of quantitative level of lgG with the changes of cardiac function
Relationship between the serum hs-CRP and the quantitative level of lgG glycopeptides in peripheral blood.	12 months	correlation between the serum hs-CRP and lgG
MACEs during 12-month follow-up	12 months	Association of quantitative level of lgG with prognosis

Trial Locations

Locations (1)

The First Affiliated Hospital of Dalian Medical University; 🇨🇳 Dalian, China