Plasma renin test guided drug treatment algorithm for correcting different subtypes of hypertension in treated but uncontrolled patients

Not Applicable

Completed

• Conditions: Hypertension, treated but uncontrolled; Circulatory System; Hypertension secondary to other renal disorders

• Registration Number: ISRCTN15531697
• Lead Sponsor: Second Hospital of Hebei Medical University (China)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-24
• Last Update Posted: 3 July 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

1. Established hypertensive patients
2. 18 years or older
3. Male or female of any race or ethnicity
4. Have never had anti-hypertensive medication
5. Have had anti-hypertensive medication but not for at least two weeks

Exclusion Criteria

1. Any comorbidities requiring the medications that interferes with blood pressure (BP) levels (e.g. non-steroidal anti-inflammatory drugs with the exception of aspirin)
2. Any contraindications to any types of antihypertensive drug applied in this study (e.g. asthma)
3. Any situations leading to poor adherence to the study protocol (e.g. mental illness or instability in BP levels e.g. cardiovascular neurosis)
4. Home BP 135/85 mmHg
5. History of white-coat hypertension
6. Serum creatinine >2.5 mg/dl

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in change in BPs between RTGT and SGCC groups with the three hypertension subtypes, respectively, and between the three hypertension subtypes within RTGT group.

Secondary Outcome Measures

Name	Time	Method
Differences in change in the antihypertensive drug number between RTGT and SGCC groups with the three hypertension subtypes, respectively, and between the three hypertension subtypes within RTGT group.