Effects of Dialysate/Replacement Supraphysiologic Sodium Concentration and Hemodynamic Stability in Critically-ill Patients receiving Continuous Renal Replacement Therapy (CRRT) : A Randomized, Double-blinded, Controlled Study

Phase 3

• Conditions: Critically- Continuous renal replacement therapy; Continuous venovenous hemofiltration; Dialysis fluid; ill patients requiring continuous renal replacement therapy; Replacement fluid; Continuous venovenous hemodiafiltration

• Registration Number: TCTR20200108001
• Lead Sponsor: Division of Nephrology, Department of Internal Medicine, Faculty of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-08
• Study Completion: 2020-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Age of 18 years or more
2. ICU patients requiring continuous renal replacement therapy
3. Patients with adequate volume status assessed by inferior vena cava distensibility index <18 % or pulse pressure variation < 13 %
4. Patients who are being on inotropic agents
5. Patients or family members can provide consent

Exclusion Criteria

1. Patients with serum sodium levels <125 mmol/L
2. Patients with mean arterial pressure <65 mmHg with adequate dose of inotropic agents
3. Patients with severe acidosis (defined by blood pH <7.15)
4. Pregnancy
5. Uncontrolled bleeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of patients who have vasopressor dependency index change of ≥0.05 4 hours after randomization Vasopressor dependency index is calculated from inotropic score divided by mean arterial pressure