Effect of combined iron, zinc, and calcium supplementation on iron, zinc, and calcium status in adolescents

Completed

• Conditions: Micronutrient deficiencies; Nutritional, Metabolic, Endocrine; Nutritional deficiency

• Registration Number: ISRCTN11852796
• Lead Sponsor: niversity of Chile (Chile)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-20
• Study Completion: 2016-10-30
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Current inclusion criteria as of 18/01/2017:
1. Male or female
2. 16 - 18 years old
3. In good health
4. Sexual maturity rating of Tanner stage 5

Previous inclusion criteria:
1. Male or female
2. 16 - 17 years old
3. In good health
4. Sexual maturity rating of Tanner stage 5

Exclusion Criteria

1. Use of vitamin supplements containing iron, zinc, calcium, vitamin D during the last 6 months prior the beginning of the trial
2. Known intolerance/allergy to iron, zinc, and calcium supplements
3. Smoking and alcohol abuse or dependence
4. Morbidity (excepting anemia defined as hemoglobin < 120 g/L)
5. Participation in previous studies particularly involving the administration of micronutrient supplements
6. Pregnant or planning a pregnancy during the study period
7. Breastfeeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Bone mineralization (as an outcome of Ca supplementation)<br> 2. Iron nutrition status measured by:<br> 2.1. Hemoglobin<br> 2.2. Mean corpuscular volume<br> 2.3. Zn protoporphyrin<br> 2.4. Serum ferritin<br> 2.5. Total iron binding capacity<br> 2.6. Serum Iron<br> 2.7. Hepcidin<br> 2.8. Transferrin receptor<br> 2.9. Transferrin saturation<br> 2.10. Total body iron<br> 3. Zinc nutrition status measured by circulating Zn levels<br>

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration