Healthy Aging and Memory Study
- Conditions
- Alzheimer Disease
- Registration Number
- NCT00034567
- Lead Sponsor
- National Institute on Aging (NIA)
- Brief Summary
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
- Detailed Description
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in AD primary prevention trials. The new or improved measures that have been developed will then be evaluated in 650 nondemented subjects enrolled in a simulated Alzheimer's disease prevention trial. Once enrolled, subjects will be followed for four years with annual clinical evaluations and interim six-month phone calls.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 650
- 75 years or older.
- Fluent in English or Spanish.
- Stable medical condition for four weeks prior to screening visit.
- Stable medications for four weeks prior to screening visit.
- Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.5.
- mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
- Willing to participate in four to five year follow-up study.
- Willing to identify person who can serve as informant.
- At least six years education or work history sufficient to exclude mental retardation
- Meets DSM IV criteria for dementia
- History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
- Alcohol or substance abuse and/or active major psychiatric disorders
- Concurrent participation in a clinical drug trial
- History of mental retardation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (39)
Wien Center for Memory Disorders
🇺🇸Miami Beach, Florida, United States
Baumel-Eisner Ft Lauderdale
🇺🇸Ft Lauderdale, Florida, United States
Mayo Clinic, Jacksonville
🇺🇸Jacksonville, Florida, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Medical University of South Carolina
🇺🇸North Charleston, South Carolina, United States
University of California, San Diego
🇺🇸La Jolla, California, United States
Stanford/Va Aging Clinical Research Center
🇺🇸Palo Alto, California, United States
Baumel-Eisner Neuromedical Institute, Miami Beach
🇺🇸Miami Beach, Florida, United States
Mt. Sinai Medical Center
🇺🇸New York, New York, United States
New York University School of Medicine
🇺🇸New York, New York, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Columbia University
🇺🇸New York, New York, United States
Memorial Hospital of Rhode Island (Brown University)
🇺🇸Pawtucket, Rhode Island, United States
Washington University
🇺🇸St. Louis, Missouri, United States
Sun Health Research Institute
🇺🇸Sun City, Arizona, United States
Baumel-Eisner Neuromedical Institute, Boca Raton
🇺🇸Boca Raton, Florida, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
University of Kentucky, Lexington
🇺🇸Lexington, Kentucky, United States
University of California, Irvine
🇺🇸Irvine, California, United States
University of Rochester
🇺🇸Rochester, New York, United States
University of Alabama, Birmingham
🇺🇸Birmingham, Alabama, United States
University of California, Davis
🇺🇸Sacramento, California, United States
University of South Florida, Tampa
🇺🇸Tampa, Florida, United States
Emory University
🇺🇸Atlanta, Georgia, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Rush Alzheimer's Disease Center
🇺🇸Chicago, Illinois, United States
Indiana University Alzheimer's Center
🇺🇸Indianapolis, Indiana, United States
Boston University School of Medicine
🇺🇸Boston, Massachusetts, United States
Michigan Alzheimer's Disease Research Center
🇺🇸Ann Arbor, Michigan, United States
Mayo Alzheimer's Disease Center
🇺🇸Rochester, Minnesota, United States
Oregon Health Sciences University
🇺🇸Portland, Oregon, United States
University of Southern California
🇺🇸Los Angeles, California, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
University of Nevada, Las Vegas
🇺🇸Las Vegas, Nevada, United States
University Hospitals of Cleveland
🇺🇸Cleveland, Ohio, United States
University of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
University of California, Los Angeles
🇺🇸Los Angeles, California, United States