The Brain Health Study: A Pragmatic, Patient-Centered Trial
- Conditions
- Alzheimer DiseaseDementia
- Interventions
- Other: Brain Health Assessment
- Registration Number
- NCT05356702
- Lead Sponsor
- Kaiser Permanente
- Brief Summary
The eRADAR Brain Health Study seeks to refine and test a novel, low-cost strategy for increasing dementia detection within primary care.
- Detailed Description
eRADAR stands for "electronic health record (EHR) Risk of Alzheimer's and Dementia Assessment Rule." It is a low-cost tool or algorithm that uses readily available EHR data elements to identify high-risk patients. We will conduct a pragmatic randomized controlled trial to assess the impact of implementing eRADAR as part of a supported outreach process on dementia detection rates. We will also explore the impact of eRADAR implementation on healthcare utilization and patient experience.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 3417
- No prior diagnosis of dementia (defined from EHR diagnosis codes) and not receiving medications for dementia
- Active patient at participating clinic
- Adequate data to calculate eRADAR score
- Currently receiving hospice care
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Brain Health Intervention Brain Health Assessment * Calculate eRADAR scores using EHR data to identify eligible individuals * Invite eligible individuals for brain health assessment visit * Enter results of brain health assessment visit into EHR * Provide summary of results and recommended next steps to the Primary Care Physician and participant
- Primary Outcome Measures
Name Time Method New dementia diagnoses 12 months after index date Rate of new dementia diagnoses identified from the electronic health record (EHR) using a prespecified set of ICD-10 codes
- Secondary Outcome Measures
Name Time Method Urgent care/emergency department visits 1 year after index date Number of urgent care and emergency department visits
New dementia diagnoses (secondary definitions) 6 months after index date; 18 months after index date Dementia diagnosis rate in different time periods than for primary outcome, defined from EHR data
Clinic "no shows" 1 year after index date Number of scheduled visits missed
Medication adherence 1 year after index date Proportion of days covered
Dementia medications 6 months after index date Percent of participants who receive new medications for dementia, defined from medication orders or dispensings in the electronic health record
Rate of accepting brain health visit 3 months after invitation mailed Proportion of people offered a brain health visit who accept and attend the visit
Healthcare utilization 6 months after index date Number of primary care visits, laboratory tests performed, neuroimaging tests, and specialty visits or referrals, defined from EHR data
New diagnoses of mild cognitive impairment 12 months after index date Rate of new diagnoses of mild cognitive impairment following the intervention, defined from EHR data
Hospitalizations 1 year after index date Number of inpatient stays
Positive predictive value of eRADAR algorithm 12 months after index date Proportion of people with a high risk eRADAR Score who attend a brain health visit who are diagnosed with dementia
Trial Locations
- Locations (5)
Kaiser Permanente Northgate Medical Center
🇺🇸Seattle, Washington, United States
Kaiser Permanente, Capitol Hill
🇺🇸Seattle, Washington, United States
Kaiser Permanente Kent Medical Center
🇺🇸Kent, Washington, United States
Kaiser Permanente Renton Medical Center
🇺🇸Renton, Washington, United States
Kaiser Permanente Burien Medical Center
🇺🇸Burien, Washington, United States