Efficacy of olanzapine for relief of nausea with incomplete bowel obstruction in advanced cancer patient: pragmatic randomized controlled trial - Olanzapine for nausea with incomplete bowel obstruction

on-Profit Organization JORTC0 个研究点目标入组 40 人开始时间: 2013年3月26日最近更新: 2023年10月17日

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•1) Patients received chemotherapy or radiation therapy within 28 days 2) Patients diagnosed diabetes mellitus or having history of diabetes mellitus (possibility of worsening diabetes mellitus) Diagnosis of diabetes mellitus is on the basis of 1. fasting blood sugar >=126 mg/dl, 2. 2-hour blood sugar level after 75g glucose tolerance test >=200 mg/dl or 3. random blood sugar >=200 mg/dl and HbA1c >=6.5% 3) Patients administrated with dopaminergic drugs such as phenothiazine, butyrophenone and atypical antipsychotic within 3 days 4) Patients with nasogastric tube, percutaneous endoscopic gastrostomy and percutaneous trans-esophageal gastro-tubing 5) Patients with indication of surgery or chemotherapy 6) Patients with bowel obstruction due to non malignant disease 7) Patients with complete bowel obstruction 8) Patients with signs of gastrointestinal tract perforation or sepsis 9) Patients with incidence of colic pain (paroxysmal and repetitive abdominal pain) within 48 hours 10) Patients with high risk of colic pain according to metoclopramide 11) Patients who are judged to be inappropriate for the study by the responsible researcher 12) Patients lacking in ability to make suitable decisions 13) Patients who are judged to be inappropriate for the study by the physician

发起方

on-Profit Organization JORTC