Prognostic Value of a Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 923
- 试验地点
- 1
- 主要终点
- overall survival
研究概览
简要总结
A suspicious circumferential resection margin (CRM), defined as tumor cells within 1 mm of the CRM, is still controversial. The aim of this study was to compare the clinical significance of a suspicious CRM to histologically positive (R1) and negative margin (R0) resections in patients with pT3 esophageal and GE-Junction tumors.
详细描述
From our prospectively build database 923 consecutive pT3 patients operated between january 1990 and june 2013 were selected. CRM status in patients treated by surgery only (n = 747) or after neoadjuvant therapy (n = 176) was recorded prospectively after surgery.
Kaplan-Meier survival curves were generated, and factors affecting survival were assessed by Cox regression multivariate analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pathologic T3 tumours of esophagus or GEJ
排除标准
- •pT other than pT3
- •R2 resections
结局指标
主要结局
overall survival
时间窗: 5 years after esophagectomy
5 years overall survival after esophagectomy
次要结局
未报告次要终点
研究者
Johnny Moons
Datameanager Thoracic Surgery
University Hospital, Gasthuisberg