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临床试验/NCT04141722
NCT04141722Unknown不适用

AGE-RELATED CHANGES IN SLEEP-DEPENDENT EMOTIONAL MEMORY

University of Massachusetts, Amherst2 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2018年12月11日最近更新:
适应症

试验速览

阶段
不适用
入组人数
80
试验地点
2
主要终点
Memory bias

研究概览

简要总结

Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-30 or 50-80 years of age
  • Have no history of a sleep disorder
  • Have no history of neurological disease or injury
  • Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
  • No history of chemotherapy
  • Not be taking medications which effect sleep
  • Habitually sleep more than 6 or more hours per night
  • Be able to walk freely and independently
  • Have normal to corrected-to-normal vision

排除标准

  • 未提供

结局指标

主要结局

Memory bias

时间窗: 12 hr delay between encoding and recognition test

Corrected recognition of positive versus negative pictures

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Rebecca Spencer

Associate Professor

University of Massachusetts, Amherst

研究点 (2)

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