Quality evaluation of cultured cartilage made of isolated chondrocytes from damaged cartilage
Not Applicable
- Conditions
- Traumatic cartilage defect of the knee, Osteochondritis dissecans of the knee
- Registration Number
- JPRN-UMIN000040215
- Lead Sponsor
- Chiba University Center for Preventive Medical Sciences
- Brief Summary
Some remnant cartilage were negative in Safranin O staining and had advanced fibrosis. Compared to normal chondrocytes, they had gene expression patterns similar to those of dedifferentiated chondrocytes from OA patients. Cultured cartilage prepared from them tended to have a low cartilage matrix production ability. They showed gene expression patterns similar to that of ossified chondrocytes. These data indicated that their quality as raw materials for cultured cartilage was low.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
1) Under 15 years of age 2) Cartilage around the defect could not be collected 3) Infectious diseases (HIV, HBs, HCV, TP, HTLV-1) positive or untested 4) Infomed consent not obtained
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ECM production ability of the prepared cultured cartilage
- Secondary Outcome Measures
Name Time Method